Decreased Nitric-oxide Synthase Activity Causes Impaired Endothelium-dependent Relaxation in the Postischemic Heart
نویسندگان
چکیده
منابع مشابه
Roles of constitutive nitric oxide synthase in postischemic rat retina.
PURPOSE Nitric oxide is a reactive species that could be protective or destructive to the retina depending on the stage of the evolving ischemic process. This study was conducted to obtain a better understanding of the roles of constitutive nitric oxide synthase (cNOS) during reperfusion after ischemia in rat retina. METHODS Retinal ischemia was induced for 60 minutes in Sprague-Dawley rats b...
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Nitric oxide (NO) is generated from the conversion of L -arginine to L-citrulline by endothelial nitric oxide synthase (eNOS), which requires Ca/calmodulin, FAD, FMN, and tetrahydrobiopterin (BH4) as cofactors. Chemical studies in vitro demonstrated that the catalytic mechanisms of NOS involve flavin-mediated electron transport from a flavincontaining reductase domain to a heme-containing oxyge...
متن کاملNitric oxide and nitric oxide synthase activity in plants.
Research on NO in plants has gained considerable attention in recent years mainly due to its function in plant growth and development and as a key signalling molecule in different intracellular processes in plants. The NO emission from plants is known since the 1970s, and now there is abundant information on the multiple effects of exogenously applied NO on different physiological and biochemic...
متن کاملData Supplements Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery
Tissue preparation The segments of the right coronary arteries (2-3 cm from the origin) were excised from the porcine hearts at a local slaughterhouse immediately after the animals had been slaughtered. The segments were brought back to the laboratory in ice-cold normal physiological salt solution (PSS). After removing the adventitia, the segments were cut into strips in a circular direction, a...
متن کاملPlasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery.
OBJECTIVE Plasmin is a key enzyme in fibrinolysis. We attempted to determine the possible role of plasmin in the regulation of vascular tone, while also investigating the mechanism of plasmin-induced vasorelaxation. METHODS AND RESULTS In porcine coronary artery, plasmin induced an endothelium-dependent relaxation. This relaxing effect was mostly abolished by a proteinase inhibitor, a plasmin...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.34.21420